R&D-Driven Custom Peptide Solutions
R&D Capabilities
Utide’s R&D team offers deep practical expertise in peptide drug development, covering peptide synthesis, process development, and analytical characterization. With more than 20 years of hands‑on experience, the team excels at transforming complex peptide designs into robust, reproducible manufacturing processes.
The team specializes in process design for long‑chain and modified GLP‑1 class peptides, with established expertise in sequence optimization, long‑acting modification strategies, and process implementation—supporting technically demanding development‑stage programs.
Building on strong R&D foundations and deep peptide chemistry expertise, we translate development capabilities into flexible, project-specific custom peptide solutions.
Comprehensive Custom Peptide Synthesis Capabilities
From Sequence Design to Impurity Control — We Deliver More Than Peptides, We Deliver Solutions
Successful peptide development hinges not only on synthesis, but also on a thorough understanding of sequence complexity, structural behavior, modification strategy, and quality risk control.
We provide end-to-end custom peptide solutions, supporting clients from early research through advanced preclinical and pharmaceutical applications.
01
Customized Amino Acid Sequences
Designing Challenging Sequences
We specialize in challenging and non-standard sequences through proactive design analysis and process optimization.
· Broad Length Coverage
Reliable synthesis of peptides ranging from short sequences (2–10 amino acids) to long peptides exceeding 100 amino acids, with consistent yield and batch reproducibility.
· Special and Non-Natural Building Blocks
Full compatibility with D-amino acids, non-natural amino acids (e.g. Cit, Orn, Abu), β-amino acids, and other customized monomers beyond the 20 canonical amino acids.
· Advanced Solutions for Difficult Sequences
Targeted strategies for highly hydrophobic, aggregation-prone, or cysteine-rich peptides, supported by sequence feasibility evaluation, optimized coupling protocols, and microwave-assisted peptide synthesis technologies.
· Targeted strategies for highly hydrophobic,
aggregation‑prone, or cysteine‑rich peptides, supported by sequence feasibility assessment, optimized coupling protocols, and microwave‑assisted synthesis.
02
Modification Versatility
Enabling Functionality Through Precise Structural Engineering
Peptide modification is critical for tuning biological activity, stability, and pharmacokinetic properties. We offer a comprehensive portfolio of standard and advanced modifications.
· Terminal Modifications
Acetylation
Amidation
Biotin Labeling
Fluorescent Tags (FITC, FAM)
· Structural Constraints and Cyclization
Disulfide bond formation (single or multiple)
lactam bridge cyclization
hydrocarbon-stapled peptides.
· Functional Modifications
Phosphorylation (p-Ser, p-Thr, p-Tyr)
· lipidation (e.g. palmitic acid, myristic acid)
· Conjugation Technologies
Peptide conjugation to carrier proteins (KLH, BSA, OVA) or polymers such as PEG.
03
Salt Form & Counter-Ion Control
Precision Down to the Final Chemical Form
Salt form selection plays a critical role in peptide stability, solubility, and experimental reproducibility. We provide precise control tailored to downstream applications.
· Common Salt Forms Available
TFA salts (default), acetate salts, and hydrochloride (HCl) salts.
· Desalting and Salt Exchange
Ultra-low residual TFA levels (≤1%) achievable, meeting the stringent requirements of cell-based assays and toxicity-sensitive studies.
· Customized Counter-Ions
Sodium, ammonium, and other customized salt forms available to match specific buffer systems or formulation requirements.
04
Flexible Purity Levels
Optimized Purity Based on Application Needs
Rather than a one-size-fits-all approach, we recommend purity levels aligned with experimental purpose, ensuring both performance and cost efficiency.
| Purity | Applications | Quality Assurance |
| Crude / >70% | Early Screening | Molecular weight confirmation by MS |
| High-throughput Assays | ||
| >85% | Immunological Studies | HPLC purity analysis |
| Peptide Antibody Production | ||
| >95% | In vitro Biochemical Assays | Publication-grade quality |
| Receptor–ligand Studies | ||
| >98% / GMP Grade | Preclinical Studies | UPLC and advanced release testing |
| Drug Discovery | ||
| Structural Biology |
05
Impurity Profile & Quality Insight
The True Measure of Professional Peptide Manufacturing
Quality excellence extends beyond the main peak. Our impurity profiling strategy reflects a deep understanding of synthesis-related risks.
· Process-Related Impurity Control
Identification and control of deletion sequences, incomplete deprotection products, and oxidation-related impurities.
· Water Content & Residual Solvent Testing
Strict monitoring of moisture levels and residual organic solvents to ensure stability and regulatory readiness.
· Endotoxin Control
Endotoxin testing available for peptides intended for cell-based and animal studies, with levels as low as <0.01 EU/mg, ensuring biological assay integrity.
Address
Standardized Factory Building 7, 4th Floor, Pharmaceutical Product Trading Center, Shenxi Town，Honghuagang District, Zunyi City,Guizhou Province
1603-1, Wanxia Center,Tower C, Phase ll of Haijingjie Jiayuan, No. 27, Zhaoshang EastRoad, Dongjiaotou Community，Shekou Sub-district, Nanshan District，Shenzhen City, Guangdong Province,China
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