Tirzepatide
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Our products are intended for research use only. They are not permitted for any human or animal consumption.
Our products are intended for research use only. They are not permitted for any human or animal consumption.
Parameter
Product Number ： U3902
CAS number ： 2023788-19-2
Molecular formula ： C₂₂₅H₃₄₈N₄₈O₆₈
Synthesis method ： Solid-phase chemical synthesis
Product characteristics ： White powder
Molecular weight ： 4813.53
作用机制COAHPLCDetail
Tirzepatide is a novel dual receptor agonist of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1). Under normal physiological conditions after food intake, the intestine releases endogenous GIP and GLP-1 hormones, which promote insulin secretion, suppress appetite, delay gastric emptying, and enhance satiety. Tirzepatide mimics the actions of these naturally occurring hormones by activating both GIP and GLP-1 receptors in the body.
Research Applications:
- Dual receptor agonist mechanism
- Type 2 diabetes treatment
- Weight management studies
| 检测项目 Tests | 接受标准 Acceptance Criteria | 结果 Results | |
| 溶解性 Solubility | 可溶于纯水中，浓度达 5 mg/ml Can be dissolved to 5 mg/ml in pure water | 符合 Confirms | |
| 分子离子质量 Molecular Ion Mass | 4813.53 ± 1.0 | 符合 Confirms | |
| pH | 7.0–9.0（C = 5 mg/ml） | 7.6 | |
| 水分含量（KF） Water Content (KF) | 不得超过 8.0% NMT 8.0% | 2.20% | |
| 纯度（HPLC） Purity (HPLC) | 不得低于 98.0% NLT 98.0% | 99.36% | |
| 有关物质（HPLC） Related substances (HPLC) | 最大单一杂质含量不得超过 1.0% The largest individual impurity test NMT 1.0% | 0.19% | |
| 总杂质含量不得超过 2.0% The total impurities test NMT 2.0% | 0.64% | ||
| 残留溶剂（GC） Residual solvent (GC) | 二氯甲烷 Methylene chloride | 不得超过 600 ppm NMT 600 ppm | 未检出 N.D |
| 乙腈 Acetonitrile | 不得超过 410 ppm NMT 410 ppm | 128 ppm | |
| 甲醇 Methanol | 不得超过 3000 ppm NMT 3000 ppm | 未检出 N.D | |
| N,N-二甲基甲酰胺 N,N-Dimethylformamide | 不得超过 880 ppm NMT 880 ppm | 未检出 N.D | |
| 异丙醚 Isopropyl ether | 不得超过 5000 ppm NMT 5000 ppm | 未检出 N.D | |
| 三乙胺 Triethylamine | 不得超过 320 ppm NMT 320 ppm | 未检出 N.D | |
| 叔丁基甲基醚 Tert-butyl methyl ether | 不得超过 5000 ppm NMT 5000ppm | 未检出 N.D | |
| 酸性基团离子（HPLC） Acid group ions (HPLC) | 三氟乙酸（TFA） | 不得超过 0.1% NMT 0.1% | 未检出 N.D |
| 磷酸根（PO₄³⁻） | 不得超过 0.1% NMT 0.1% | 未检出 N.D | |
| 乙酸（HAC） | 不得超过 0.1% NMT 0.1% | 未检出 N.D | |
| 细菌内毒素 Bacterial Endotoxins | 不得超过 10 EU/mg NMT 10 EU/mg | 符合 Confirms | |
| 微生物限度 Microbial Limits | 需氧菌总数 TAMC | 不得超过 1000 cfu/g NMT 1000 cfu/g | 符合 Confirms |
| 酵母和霉菌总数 TYMC | 不得超过 100 cfu/g NMT 100 cfu/g | 符合 Confirms | |
| 大肠杆菌存在性 Escherichia Coil presence | 阴性 Negative | 符合 Confirms | |
| 沙门氏菌 Salmonella | 阴性 Negative | 符合 Confirms | |
| 铜绿假单胞菌 P. Aeruginosa | 阴性 Negative | 符合 Confirms | |
| 金黄色葡萄球菌 S. Aureus | 阴性 Negative | 符合 Confirms | |
| 高分子蛋白 High Molecular Protein | 不得超过 0.50% NMT 0.50% | 未检出 N.D | |
| 钠离子 Sodium ion | 不得超过 5.0% NMT 5.0% | 1.10% | |
| 多肽含量（质量平衡法） Peptide Content (Mass Balance) | 不得低于 80.0% NLT 80.0% | 961.00% | |
| 含量测定（HPLC） Assay (HPLC) | 95.0–105.0%（以无水、无盐基准计） 95.0–105.0% (on anhydrous and salt-free substance basis) | 99.50% | |
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