Semaglutide
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Our products are intended for research use only. They are not permitted for any human or animal consumption.
Our products are intended for research use only. They are not permitted for any human or animal consumption.
Parameter
Product Number ： U3101
CAS number ： 910463-68-2
Molecular formula ： C₁₈₇H₂₉₁N₄₅O₅₉
Synthesis method ： Solid-phase chemical synthesis
Product characteristics ： White powder
Molecular weight ： 4113.58
作用机制COAHPLCDetail
Semaglutide is a synthetically engineered analogue of human glucagon-like peptide-1 (GLP-1) that exerts its effects by activating the GLP-1 receptor. GLP-1 is an incretin hormone secreted by L cells located in the distal ileum and colon. The structure of semaglutide has been modified based on native GLP-1 to resist enzymatic degradation and to enable strong binding to serum albumin in the bloodstream. Activation of the GLP-1 receptor stimulates insulin secretion and suppresses glucagon release, thereby effectively regulating blood glucose levels. In addition, it delays gastric emptying and reduces appetite, contributing to body-weight control.
Research Applications:
-Type 2 diabetes treatment
-Weight management studies
-Cardiovascular risk reduction research
| 检测项目 Tests | 接受标准 Acceptance Criteria | 结果 Results | |
| 溶解性 Solubility | 可溶于纯水中，浓度达 5 mg/ml Can be dissolved to 5mg/ml in pure water | 符合 Confirms | |
| 分子离子质量 Molecular Ion Mass | 4113.6 ±1.0 | 符合 Confirms | |
| pH | 7.0–9.0（C = 5 mg/ml） | 7.5 | |
| 水分含量（KF） Water Content (KF) | 不得超过 8.0% NMT 8.0% | 2.60% | |
| 纯度（HPLC） Purity (HPLC) | 不得低于 99.0% NLT 99.0% | 99.25% | |
| 有关物质（HPLC） Related substances (HPLC) | 最大单一杂质含量不得超过 0.5% The largest individual impurity test NMT 0.5% | 0.31% | |
| 总杂质含量不得超过 1.0% The total impurities test NMT 1.0% | 0.75% | ||
| 残留溶剂（GC） Residual solvent (GC) | 二氯甲烷 Methylene chloride | 不得超过 600 ppm NMT 600 ppm | 未检出 N.D |
| 乙腈 Acetonitrile | 不得超过 410 ppm NMT 410 ppm | 177 ppm | |
| 甲醇 Methanol | 不得超过 3000 ppm NMT 3000 ppm | 未检出 N.D | |
| N,N-二甲基甲酰胺 N,N-Dimethylformamide | 不得超过 880 ppm NMT 880 ppm | 未检出 N.D | |
| 异丙醚 Isopropyl ether | 不得超过 5000 ppm NMT 5000 ppm | 未检出 N.D | |
| 三乙胺 Triethylamine | 不得超过 320 ppm NMT 320 ppm | 未检出 N.D | |
| 叔丁基甲基醚 Tert-butyl methyl ether | 不得超过 5000 ppm NMT 5000ppm | 未检出 N.D | |
| 酸性基团离子（HPLC） Acid group ions (HPLC) | 三氟乙酸（TFA） | 不得超过 0.1% NMT 0.1% | 未检出 N.D |
| 磷酸根（PO₄³⁻） | 不得超过 0.1% NMT 0.1% | 未检出 N.D | |
| 乙酸（HAC） | 不得超过 0.1% NMT 0.1% | 未检出 N.D | |
| 微生物限度 Microbial Limits | 需氧菌总数 TAMC | 不得超过 1000 cfu/g | 符合 Confirms |
| 酵母和霉菌总数 TYMC | 不得超过 100 cfu/g | 符合 Confirms | |
| 大肠杆菌存在性 Escherichia Coil presence | 阴性 Negative | 符合 Confirms | |
| 沙门氏菌 Salmonella | 阴性 Negative | 符合 Confirms | |
| 铜绿假单胞菌 P. Aeruginosa | 阴性 Negative | 符合 Confirms | |
| 金黄色葡萄球菌 S. Aureus | 阴性 Negative | 符合 Confirms | |
| 钠离子 Sodium ion | 不得超过 4.0% NMT 4.0% | 3.40% | |
| 细菌内毒素 Bacterial Endotoxins | 不得超过 10 EU/mg NMT 10 EU/mg | 符合 Confirms | |
| 含量（UPLC） Assay (UPLC) | ≥95.0% | 98.50% | |
| 存储 Storage | 保持在密闭容器中，避光保存，储存温度为 -20±5℃ Keep in tight container, protect from light, store at a temperature of -20±5℃ | ||
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