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Amycretin

Amycretin

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Parameter
Product Number U6801
CAS number 3005889-81-3
Molecular formula C₃₄₃H₅₅₀N₉₄O₁₁₆
Synthesis method Solid-phase chemical synthesis
Product characteristics White powder
Molecular weight 7846.6 ± 1.0
Reservation Now
作用机制COAHPLCDetail

Amycretin is a novel single-molecule peptide drug that combines two covalently linked analogues of GLP-1 and amylin, creating a dual agonist of the GLP-1 and amylin receptors. Its structure enhances both appetite regulation and metabolic control. By activating GLP-1 pathways to reduce hunger and amylin pathways to slow gastric emptying and improve satiety, amycretin supports powerful, sustained weight reduction.


Research Applications:
  • Activates GLP-1 and amylin pathways to support metabolic regulation.

  • Helps reduce appetite and enhance satiety signals.

  • Slows gastric emptying to aid weight-management efforts.

  • Investigated for obesity and broader metabolic health applications.


项目 Items标准 Standard结果 Results
外观
Appearance
白色或类白色粉末
White or off-white powder
白色粉末
White powder
分子量
Molecular Ion Mass
7846.6 ± 1.0符合
Conforms
溶解度
Solubility
在纯水中可溶解至浓度为 50 mg/ml
Can be dissolved to 50 mg/ml in pure water
符合
Conforms
酸碱度
pH
7.0–9.08.1
水分(K.F)
Water Content (K.F)
≤ 8.0%3.50%
纯度(UPLC)
Purity (UPLC)
≥ 95.0%97.23%
有关物质(UPLC)
Related Substance (UPLC)
总杂
Total impurities
≤ 5.0%2.77%
最大单一杂质
Largest individual impurity
≤2.0%0.62%
残留溶剂(GC)
Residual Solvent (GC)
二氯甲烷
Methylene chloride
≤ 600 ppm未检出
N.D
乙腈
Acetonitrile
≤ 410 ppm166 ppm
甲醇
Methanol
≤ 3000 ppm未检出
N.D
N,N-二甲基甲酰胺
N,N-Dimethylformamide
≤ 880 ppm未检出
N.D
叔丁基甲醚
Isopropyl ether
≤ 5000 ppm未检出
N.D
酸根离子(IC)
Acid Group Ions (IC)
三氟乙酸
TFA
≤ 0.1%未检出
N.D
磷酸根
PO₄³⁻
≤ 0.1%未检出
N.D
醋酸根
HAC
≤ 0.1%未检出
N.D
钠离子(IC)
Sodium Ion (IC)
≤ 4.0%3.20%
微生物限度
Microbial Limits
需氧微生物总数
TAMC
≤ 1000 cfu/g符合
Conforms
酵母和霉菌总数
TYMC
≤ 100 cfu/g符合
Conforms
细菌内毒素
Bacterial Endotoxins
≤ 10 EU/mg符合
Conforms
含量测定(UPLC)
Assay (UPLC)
≥ 90.0%96.80%
储存
Storage
保存至密闭容器中,避光保存,储存温度为 -20±5℃
Keep in tight container, protect from light, store at a temperature of -20±5℃

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